The short answer is yes there are measurable things you can see when premilling, but keep in mind we can measure some pretty small things.
I've worked for breweries that this was a huge no from due to the effects that we would measure on flavor stability when approaching the end of our shelf life. While they were measurable quantitatively we didn't see it sensorily stand out as much versus beers that were not milled in.
Many brewers out there are making great beers that buy pre milled malt and as long as you don't have shelf life issues won't be perceived by the customer.
I would recommend staying away from light lagers or low hopped beers as you might see some earlier oxidation characteristics come up but I really suspect you won't.
It might not hurt to pre grind a batch in your current facility or if you have a small pilot just give it a test. I would let your premilled go over the weekend and see. I suspect your panel won't be able to tell a difference base upon personal experience.
------------------------------
Timothy Hawn
Director of Operations
Craft Kettle Brewing Equipment
------------------------------